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The experiments were approved by the Commission on Biomedical Ethics of the Zakusov Institute of Pharmacology

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK/PI3K/AKT-mediated oxidative stress

5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT)

Vitamin B12 deficiency can be occurring while vitamin B12 levels are at levels not typically associated with deficiency due to the presence of deleterious MTHFR mutations